You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.
However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.
Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.
Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.
Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.
Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:
Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.
Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.
Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.
The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.
In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.
Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.
So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.
However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.
Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.
Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.
Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.
We’d generally recommend trying Second Nature’s before considering a weight-loss jab.
Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.
At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.
In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.
Second Nature was more than twice as effective at supporting weight loss than the other four providers.
However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.
Potential side effects:Healthy weight loss
Top tips for healthy weight loss:
To help you find out if you have a healthy body weight, measure your and waist circumference To lose weight, the energy you take in from food must be less than the energy you use – eat less, move more!
Set yourself realistic goals to achieve a healthy weight. Even small amounts of weight loss can have significant health benefits and can help to set you on a path to a healthier future. Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week
Weight loss can reduce your risk of: heart disease, stroke, type 2 diabetes and some cancers.
It can also reduce the risk of:
High blood pressure Angina (heart condition causing chest pain) High blood cholesterol levels Lower back and joint pain Fertility problems BMI and waist circumference
For most adults:
A BMI between 18.5 and 25 is defined as healthy. A BMI of over 25 is defined as overweight. A BMI of over 30 is defined as obese.
Waist-circumferences for which there is an increased risk and high risk of obesity-related health problems:
Increased risk High risk Men ≥94 cm (37 in) ≥102 cm (40 in) Women ≥80 cm (31.5 in) ≥88 cm (34.5 in)
Sensible weight loss should be seen as an overall lifestyle change which involves eating a healthy balanced diet and doing plenty of physical activity.
Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week. This way, the weight is more likely to stay off. This rate of weight loss is based on using up 600 kcal per day more than you take in. On average, this means consuming no more than 1,400 kcal a day if you are a women, and no more than 1,900 kcal a day if you are a man. The amount of weight you lose will depend on how much weight you need to lose and how active you are.
Further information can be found on the manufacturers
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Orlistat.
The majority of unwanted effects related to the use of Orlistat result from its local action in your digestive system. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Very common (may affect more than 1 in 10 people):
headache abdominal pain/discomfort urgent or increased need to open the bowels flatulence (wind) with or without discharge oily discharge, oily or fatty stools liquid stools low blood sugar levels (experienced by some people with type 2 diabetes) upper respiratory infections flu (influenza)
Do not take Orlistat if you:
have a history of heart disease or severe liver problems
have ever had a heart attack or stroke, or are already suffering from serious heart problems such as heart failure
are pregnant or plan to become pregnant (you cannot take Orlistat if you are pregnant). It could theoretically cause a heart attack or stroke. If you become pregnant or breast-feeding, tell the doctor before taking Orlistat.
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have a history of liver problems or of jaundice following treatment with Orlistat.
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have ever had an eye problem such as that of eyeshadow or any other type of vision loss, or if you are severely dehydrated (you are more than 12 weeks pregnant). Or you have very low blood levels of folic acid, are taking oxalates or you are taking any other weight-lossasuring antifungal medications you can use with Orlistat.
Xenical 120mg Capsules,when used in conjunction with a reduced-calorie diet, can be used for obesity management, including weight loss and weight maintenance.Xenicalworks in your digestive system to block one-third of the fat in the food you eat from being digestedThe daily intake of fat, carbohydrate and protein should be distributed over three main meals.pills can also block the absorption of some vitamins. You may wish to take a multivitamin supplement along with making sure to keep a well-balanced diet, rich in fruit and vegetables.
The active substance isOrlistat. Each capsule contains120 mg of Orlistat
The other ingredients are microcrystalline cellulose (E460), sodium starch glycolate (type A), povidone (E1201), sodium laurilsulfate and talc. The capsule shell consists of gelatine, indigo carmine (E132), titanium dioxide (E171) and edible printing ink.
84 Capsules
WeizingNotifyNotify>Yes paralysis is common; however, there is limited information on how Xenical may affect other types of notifying systems.Notify your pharmacist if you experience any side effects, including: nausea, stomach pain, or vomiting. NauseaIUSmannageManagement of weight loss, including weight maintenance, is a complex matter. You should evaluate your health history, including any pre-existing medical conditions, before starting any weight loss medication.when used in conjunction with a reduced-calorie diet, can be used for obesity management.works in your digestive system to blockers of the fat in the food you eat. The daily intake of fat, carbohydrate and protein should be distributed over three main meals.
WeizeWeighNotifyNotify>Yes Diabetes can affect daily functioning and quality of life. This is especially important for you if you have a history of other diabetes diseases or if you have pre-existing cardiovascular or cerebrovascular disease. You should discuss your diabetes history with your doctor before starting or changing any diet.- Weighing different aspects of your health makes a big difference in deciding whether or not to take Xenical 120mg Capsules, which contains Orlistat. - Daily functioning is an important aspect of your daily life, and - Weighing different aspects of your health makes a big difference in deciding whether to take Xenical 120mg Capsules, which contains Orlistat. - Financial problems can impact your daily functioning. - Financial issues can affect your daily functioning. - Pain and discomfort are two other things you’re expected to get from taking Xenical Capsules, and - Weighing different aspects of your health makes a big difference in deciding whether to take Xenical Capsules, which contains Orlistat. - Lifestyle changes can help with weight management. - You may be able to change how you feel about yourself and how you look after yourself while taking Xenical Capsules, which contains Orlistat capsules. - - You can take Xenical Capsules, or other diabetes medications, with or without food.Xenical 120mg Capsules, when used in conjunction with a reduced-calorie diet, can be used for obesity management.
Orlistat 120 mg Capsuleis a prescription medication used to help individuals lose weight. It is available under the brand names Orlistat 120 and Orlistat 120mg. It contains the active ingredient orlistat which is designed to reduce fat absorption. The active ingredient orlistat works by blocking the absorption of dietary fats. This action helps to reduce weight in the body, which is why it is commonly prescribed by doctors in order to help people lose weight. Orlistat 120 mg is an FDA-approved medication, and its availability can vary depending on the brand. The brand name of Orlistat 120 is known under the brand name Xenical 120mg. Orlistat 120mg is also available as a generic equivalent to Orlistat 120mg. These medications are prescribed only for individuals who have an intolerance to some forms of the orlistat in this class of medications. When someone takes orlistat 120 mg orlistat, they may be limited by their doctor to only a few prescription medications. People who are pregnant, breastfeeding, or planning to get pregnant, are generally not recommended taking this medication.
Orlistat 120mg Capsuleis a prescription medication that is used for the treatment of obesity. It works by inhibiting the absorption of fats from the diet and by reducing the absorption of some vitamins and minerals. This medication is available under the brand name Xenical 120mg. The brand name of Orlistat 120mg Capsule is Xenical 120mg. This action helps to reduce weight in the body, which is why it is commonly prescribed by doctors to help people lose weight. The brand name of Orlistat 120mg is known under the brand name Xenical 120mg. This medication is also available as a generic equivalent to Orlistat 120mg. People who are pregnant, are planning to get pregnant, or are breastfeeding are generally not recommended taking this medication.
is a prescription medication used to help people lose weight. It is available under the brand name Xenical 120mg. The brand name of Orlistat 120mg is Xenical 120mg. Orlistat 120 mg is also available as a generic equivalent to Orlistat 120mg.